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KMID : 0359320190590040219
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Korean Journal of Veterinary Research
2019 Volume.59 No. 4 p.219 ~ p.222
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Nailbed malignant melanoma in three dogs
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Jo Hyoung-Nam
Suh Myeong-Won
Lee Joo-Ok
Kim Jae-Hoon
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Abstract
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Three 8-12-year-old male cocker spaniels presented with an appendicular mass accompanied by pain, inflammation, lameness, and loss of nail in the digits of the forelimb or hindlimb. A histological examination revealed dermal masses of the digit composed of numerous neoplastic cells with marked pleomorphism and high mitosis. The neoplastic cells showed a strong invasive tendency into the epidermis and adjacent bony tissues, such as distal phalanx. Immunohistochemistry of the neoplastic cells in three masses revealed positive reactions for Melan-A. These three dogs were diagnosed as nailbed malignant melanoma in the digit based on the history, clinical signs, and histopathologic features.
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KEYWORD
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digit, distal phalanx, dog, Melan-A, nailbed malignant melanoma
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